Midfielder Frank Lampard and defenders Ashley Cole and Gary Cahill are available for Thursday's friendly with City in St Louis, but will then return to London to join up with England.
Cahill told the club's official website: "We will train for the next couple of days and will be involved in the game on Thursday and then fly back on Friday."
Chelsea's 69-game season ended in Europa League success and a third-place finish in the Premier League, and Cahill was pleased they managed to sign off with some silverware.
"I think you have to say we finished strongly," he said. "We got the third position we were aiming for and achieved what we wanted there, and we finished with a trophy.
"We had ups and downs but like last year we finished well and we can be pleased.
"You've got to judge it by where you are in the league at certain stages.
"At three quarters of the way we were looking for third and we managed to achieve that.
"After we went out of the FA Cup we had one trophy left and it was important to pick up some silverware."
Chelsea's second match against Manchester City takes place in New York on Saturday.