Wanderers' Adams Park home will host the friendly on 21 March - four days before Pearce's youngsters take on Austria U21s in Brighton.
The manager said: "I've visited Wycombe many times and it is a great venue for football, the size of the stadium is perfect for us. I've never taken a team there before, so I'm really looking forward to it.
"With the senior team having two away matches in March, it's great for the U21 side to have two home matches at two different stadiums, such as Wycombe and Brighton.
"It's also a chance for the people of Buckinghamshire to come out and see some real top quality young players on show.
"It's an important month for us as it's my last opportunity ahead of this summer's tournament to look at any players. I will be putting out a strong side for both games and having a look at all my squad before we fly to Israel."