Villa's 1-0 defeat to Manchester City on Monday left the Villans level on points with 17th-placed Wigan, but in the drop zone courtesy of a -27 goal difference.
bet365 spokesman Steve Freeth said: "Villa's chances of avoiding the drop will be a lot clearer after their forthcoming relegation double header against Reading and QPR."
bet365 make the trio of Reading, QPR and Aston Villa their 2/1 favourites to fill the three relegation spots this season.
2012/13 Premier League - To Be Relegated:
Aston Villa 8/11
Villa, QPR & Reading 2/1
QPR, Reading & Wigan 11/4
Villa, QPR & Wigan 8/1
Villa, Reading & Wigan 8/1
QPR, Reading & Southampton 12/1
Villa, QPR & Southampton 20/1
QPR, Southampton & Wigan 25/1
Villa, Reading & Southampton 28/1