Fulham v Arsenal (12:45pm):
Arsenal are without the suspended Laurent Koscielny and injured Alex Oxlade-Chamberlain.
Scott Parker and Darren Bent are both hoping to be handed Fulham debuts by Martin Jol. Read full Fulham v Arsenal preview
Ahead of the London derby, Arsene Wenger has again defended his club's work in the transfer market and insists he will make signings this summer, saying: "Anything can happen until the last minute."
Everton v West Brom:
Nicolas Anelka is the headline absentee, with Steve Clarke admitting the striker is considering retirement following the death of his agent.
Scott Sinclair could make his debut for the Baggies, while, Everton will be without Sylvain Distain. Read full Everton v West Brom preview
Hull v Norwich:
Steve Bruce has the rare luxury of a fully-fit squad to choose from for his side's first home game of the season.
New boys Tom Huddlestone and Jake Livermore will both hope to start for Hull after coming off the bench at Chelsea last week and Bruce believes the pair are good enough for England.
Newcastle v West Ham:
Andy Carroll misses out against his former side but the West Ham striker is edging closer to a return.
Newcastle will be without defender Steven Taylor and Jonas Gutierrez after their poor start to the season at Manchester City last Monday. Loic Remy also remains on the sidelines. Read full Newcastle v West Ham preview
Alan Pardew admits he is taking the Yohan Cabaye situation "day-by-day" and the manager is yet to decide whether to include the midfielder against the Hammers, despite saying that no new bids had been received since Arsenal's disrespectful offer earlier this week.
Pardew is still hoping to spend, but Sam Allardyce claims West Ham are finished in the transfer market.
Southampton v Sunderland:
Ahead of Osvaldo's possible debut, Saints boss Mauricio Pochettino has sought to reassure England goalscorer Rickie Lambert over his future at St Mary's after the signing of the Italy striker.
Stoke v Crystal Palace:
Wilson Palacios been ruled out "for a few weeks" after a minor operation, and Mark Hughes is expected to make few changes to the side that pushed Liverpool close on the opening day.
Winger Jason Puncheon could go straight into Palace's side following his season-long loan move from Southampton. Read full Stoke v Crystal Palace preview
Ian Holloway had until Friday afternoon to respond to his FA charge of improper conduct but the Palace boss admits he gets "too emotional" and says "too much".
Aston Villa v Liverpool - Saturday Night Football, 5:30pm:
Ciaran Clark is expected to recover from the head injury he sustained at Chelsea, while Chris Herd is also in contention.
Liverpool striker Luis Suarez remains the only notable absentee for Brendan Rodgers, who could hand a debut to new signing Aly Cissokho. Read full Aston Villa v Liverpool preview
Ahead of the Villa Park clash, Rodgers has again been talking about Suarez, saying it would be "very difficult at this time" for any bid for the striker to succeed. Is that a softening in Liverpool's previous stance that the Uruguayan was not for sale at any cost?
Tottenham v Swansea (4pm):
Both sides are assessing players after their Europa League exploits on Thursday night, but Aaron Lennon is expected to be available for Tottenham after being rested due to a slight foot injury.
Swansea are boosted by the return of Jonathan de Guzman but Nathan Dyer remains sidelined. Read full Tottenham v Swansea preview
Spurs were all set to sign Willian but Chelsea appear to have secured the Brazilian's services. Chelsea's interest may come as a surprise to Andre Villas-Boas, who on Thursday night was unaware of any rival offer from the Blues.
Cardiff v Manchester City (4pm):
The visitors have problems at centre-half, with Vincent Kompany ruled out for around a month. Matija Nastasic could return, though, with Micah Richards also hoping to make a quick recovery.
Andreas Cornelius is in line for his Cardiff debut after getting over the ankle injury which kept him sidelined for the trip to West ham last week. Read full Cardiff v Manchester City preview
Manuel Pellegrini will be hoping for more of the same from City after he praised them for their "aggressive" display against Newcastle.
Pellegrini, though, insists City will not bring in a new centre-half just because of Kompany's injury but he did not rule out strengthening his squad in that area.
Monday Night Football:
Manchester United v Chelsea (8pm):
David Moyes must decide on Wayne Rooney's participation or whether he will join Rafael, Nani, Ashley Young and Javier Hernandez on the sidelines.
David Luiz is Jose Mourinho's only injury concern. Read full Manchester United v Chelsea preview.
All eyes will be on Wayne Rooney at Old Trafford, with Jose Mourinho claiming Chelsea will be "ethical" in waiting until after the match to make another bid for the England striker.
Mourinho is also optimistic of signing Willian from under the noses of Tottenham, with just a medical to be completed before the Brazilian joins the Blues.
Moyes has had less success so far in the transfer market. The United boss today said: "There is a need to do it but there is no pressure to do it."
Remember, we will have minute-by-minute commentaries for games up and down England and Scotland in our Live Centre across the weekend, while we will also bring you the confirmed teams before games and keep you up to date during them on our Twitter account.