David Moyes' reign at Old Trafford hit another early stumbling block on Sunday as a Sergio Aguero brace - supplemented by Yaya Toure and Samir Nasri efforts - ensured a memorable day for Manchester City at the Etihad Stadium.
While Yorke accepts the defeat will send shockwaves through the club from board level right down to the fans, he remains confident the Premier League champions have what it takes to regather themselves quickly.
He told Sky Sports News: "I think we're all a bit shell-shocked at the moment. We haven't got over the result. I think you have to give credit to City for the manner in which they played. From the start to the finish, they were certainly the better team.
"City really set out their stall and came out of the blocks extremely fast. Vincent Kompany led by example at the back and they were fantastic right the way through to Sergio Aguero at the other end of the pitch. People like Jesus Navas, Fernandinho and Samir Nasri were also outstanding yesterday.
"United couldn't get to grips with the game. They didn't have a lot of fluency in the game and that's all down to City. United didn't play anything like close to their potential. Losing Robin van Persie was a big blow to them before the game but they still had enough in that team to get a result.
"The one thing United are always good at is coming back from a defeat like that. I'm expecting a reaction to that. It's a very dark day for the red half of Manchester - the players will know that and the manager will know that. They've just got to put it behind them. It's all about the next game."
With United hosting Liverpool in the Capital One Cup on Wednesday night, Yorke believes Moyes will send out a team hungry to right the wrongs of Sunday afternoon.
He said: "The players will want to rectify it. They will want to put on a good performance - certainly at home against Liverpool. I'm expecting changes in that team as well because there are a lot of players who want to prove a point to the manager. There are places up for grabs.
"The most disappointing thing was the reaction of the players. For the first time, I have to say that I didn't see any leadership from within the United team. You look for the experience of people like Rio Ferdinand, Nemanja Vidic and Patrice Evra and we didn't get a reaction.
"David Moyes will be bitterly disappointed with that and I'm sure they'll want to put it right on Wednesday night, when they have a big game against Liverpool.
"These players have won so many trophies. There's a burning desire to retain the Premier League title. City wanted to prove a point and they came out and did that exceptionally, but it's still early stages in the season. The players will know that.
"Moyes has had a very difficult start to the season but you mention names like Rio, Vidic, Evra and Michael Carrick - they won't panic because they know they have a lot of time to recover. The fans and the manager will demand a performance and what better way to do it than on Wednesday night against Liverpool."
Another of Yorke's former employers, Sunderland, have endured problems of their own - enigmatic manager Paolo Di Canio receiving his marching orders after one point from their opening five games.
The Trinidadian added of the Black Cats vacancy: "We know one thing about Paolo Di Canio. He's a 'different' individual. He will do it his way. He managed to keep them up last season and did a fantastic job in doing that.
"He felt that he needed to make these changes and he brought in 13 or 14 new faces and got rid of 13. Sometimes, as a manager, you have to box very carefully when you're making these changes. I just think he wasn't going to be given time.
"You look at the players that he got rid of, like Stephane Sessegnon - he was arguably one of Sunderland's best players. He made all these wholesale changes and I think he needed to be a bit more subtle in making them.
"The Mackem fans will be devastated to be bottom of the league and failing to win a game. The board has reacted but these players need to look long and hard at themselves. The manager has lost his job but I feel the players that he's got simply haven't been good enough.
"Whoever comes in as the new manager will have a challenge but will probably have more time to turn things around.
"With regards to the new manager, with a lot of the Italian players that Di Canio has brought in, someone like Roberto Di Matteo would relish the opportunity. I know he's desperate to get back into management. I would think he's a candidate high on the Sunderland list.
"I do think they need to bring in some players. You've got people like Lee Cattermole and Phil Bardsley there who haven't been playing. Whoever comes in needs to get that dressing room all moving in the same direction.
"You've got Kevin Ball coming in as caretaker. I know him personally and he's very passionate and a Sunderland man through and through. I hope he can come in and steady the ship. Hopefully they can settle down and get some results under their belt."