Crystal Palace v Arsenal, 12.45pm
Key stat: Arsenal are unbeaten in 13 competitive away games, winning 11 and drawing twice.
Crystal Palace caretaker manager Keith Millen has no new injury concerns as he prepares to take charge for the first time.
Mathieu Flamini and Mesut Ozil are available for Arsenal, but Jack Wilshere faces a fitness test. Read full Crystal Palace v Arsenal preview.
Aston Villa v Everton
Key stat: Everton have not kept a clean sheet in any of their last 18 Barclays Premier League games against Aston Villa.
Christian Benteke could return to Villa's starting line-up after recovering from a hip injury, while Ciaran Clark is available after missing last week's defeat to Tottenham.
Everton, meanwhile, have a doubt over Johnny Heitinga. Read full Aston Villa v Everton preview.
Liverpool v West Brom
Key stat: Steven Gerrard has created more goalscoring chances than any other Premier League player this season (21).
Lucas Leiva is back in the Liverpool squad but neither Philippe Coutinho nor Jose Enrique are expected to be fit enough to feature for the Reds.
West Brom, meanwhile, are unlikely to risk Scott Sinclair. Read full Liverpool v West Brom preview.
Manchester United v Stoke City
Key stat: Manchester United have won all five of their previous Premier League home games against Stoke City.
United should have Robin van Persie available but are without Danny Welbeck and Tom Cleverley, while Stoke have doubts over defensive duo Ryan Shawcross and Geoff Cameron, although both could yet play. Read full Manchester United v Stoke preview.
Norwich City v Cardiff City
Key stat: Cardiff City have allowed their opponents more shots on target than any other side in the Premier League this season (51).
Ricky van Wolfswinkel's foot injury will be assessed by the Norwich medical staff ahead of the game, while Craig Bellamy is set to return to the Cardiff squad against his former club. Read full Norwich v Cardiff preview.
Southampton v Fulham, 5.45pm
Key stat: There have been just six goals scored in the four Premier League games at St Mary's this season.
Southampton have a doubt over Steven Davis but could welcome back Gaston Ramirez, while Fulham are set to be without Brede Hangeland but could hand a first appearance since August 31 to Aaron Hughes. Read full Southampton v Fulham preview.
Sunderland v Newcastle United, Sunday 1.30pm
Key stat: Sunderland have won just one of their previous 11 Tyne-Wear home derbies against Newcastle in the Premier League (D5 L5).
Wes Brown could make his first competitive appearance for Sunderland since January of last year, but Newcastle are without defensive duo Mapou Yanga-Mbiwa and Fabricio Coloccini for the crucial Wear-Tyne derby. Read full Sunderland v Newcastle preview.
Chelsea v Manchester City, Sunday 4pm
Key stat: Man City have won just two of their previous 16 Premier League trips to Stamford Bridge (L10 D4).
Ashley Cole should be available again for Chelsea.
Vincent Kompany and Martin Demichelis remain out for City, but Manuel Pellegrini has no other injury concerns. Read full Chelsea v Manchester City preview.
Swansea City v West Ham, Sunday 4pm
Key stat: Five of the eight goals that West Ham have conceded this season have been from set-piece situations - a league-high 63%.
Ashley Williams and Pablo Hernandez could return for Swansea, while West Ham have no new injury problems but remain without Andy Carroll.
Tottenham v Hull City, Sunday 4pm
Key stat: The Tigers have collected just one win from their last 28 Premier League matches away from home (L20 D7).
Danny Rose, Younes Kaboul and Etienne Capoue are set to miss out for Spurs, but Kyle Walker, Andros Townsend and Paulinho will return after being rested in the Europa League.
Hull, meanwhile, are without Jake Livermore, who is ineligible against his former club, Allan McGregor and Danny Graham. Read full Tottenham v Hull preview.