Everton v Liverpool (Sat, 12.45pm)
Key stat: Everton are currently on a run of five hours and 30 minutes without conceding a goal in the Premier League.
Luis Suarez has scored eight goals in his six Premier League appearances this season.
Everton have reported no new injury problems ahead of the game but Liverpool will be without Jose Enrique so Aly Cissokho looks set to keep his place.
Arsenal v Southampton
Key stat: Arsenal have not lost a home league game against Southampton since November 1987, winning 13 and drawing five of their 18 matches since.
Arsenal will have forward Theo Walcott back from two months out following abdominal surgery for the visit of his former club Southampton.
Jack Cork will miss Saints' trip to the capital due to an ankle injury. Read full Arsenal v Southampton preview.
Meanwhile, Arsene Wenger has denied suggestions he is annoyed with the Football Association over the fitness of midfielder Jack Wilshere.
Fulham v Swansea City
Key stat: Five of Swansea's 15 Premier League goals this season have come from set-piece situations - they only scored five in this manner in the whole of 2012-13.
The Whites have conceded a league-high six goals from corners this season.
Fulham are sweating over the fitness of key defender Brede Hangeland ahead of the visit of Swansea as he struggles to recover from a nerve problem in his leg.
While, Swansea welcome back goalkeeper Michel Vorm after he served his suspension for his sending off in the recent defeat to Cardiff. Read full Fulham v Swansea preview.
Hull City v Crystal Palace
Key stat: Crystal Palace are the only side to have failed to attempt a single shot on target in more than one Premier League game this season (0 v Man Utd and Southampton).
Hull City boss Steve Bruce is expecting Robbie Brady and Allan McGregor to be fit to face Crystal Palace, with both men having come through a full training session on Thursday.
Midfielder Jonny Williams has recovered from an ankle injury and could come into contention for Palace. Read full Hull v C Palace preview.
Newcastle United v Norwich City
Key stat: Loic Remy has scored seven goals and assisted another in his nine Premier League appearances for Newcastle United this season.
Newcastle defender Mathieu Debuchy will sit out Saturday's home date with Norwich through suspension.
Meanwhile, Norwich will again be without record signing Ricky van Wolfswinkel as the Dutch forward recovers from a toe injury. Read full Newcastle v Norwich preview.
Stoke City v Sunderland
Key stat: The Potters are also one of only three sides yet to score a headed goal in the Premier League this season, alongside Tottenham and West Ham
Mark Hughes will have to make at least one change to the side which drew last time out against Swansea City when Stoke City face Sunderland at home on Saturday.
Meanwhile, Gus Poyet will make a late check on defender Wes Brown before finalising his plans for the trip. Read full Stoke v Sunderland preview.
West Ham United v Chelsea (Sat, 5.30pm)
Key stat: Frank Lampard has scored in three of his last four Premier League appearances against former side West Ham.
However, Lampard has failed to score in 10 successive Premier League apps - his longest goal drought in the competition since April-August 2003.
Razvan Rat is doubtful with a hamstring injury sustained on international duty with Romania for when West Ham host Chelsea in the Premier League on Saturday evening.
Fernando Torres could return to aid Chelsea's bid to end a two-match winless run in the league. Read full West Ham v Chelsea preview.
Manchester City v Tottenham Hotspur (Sun, 1.30pm)
Key stat: Spurs have attempted the most shots at goal this season (157 - excluding blocked), but have the worst shot conversion rate (5.7%).
Manchester City had Sunday's game with Tottenham pencilled in for the return to action of skipper Vincent Kompany from a thigh injury, but doubts remain over his fitness.
Danny Rose is back in contention after a lengthy spell on the sidelines but Tottenham are unlikely to rush him back in for a crucial contest, meaning Jan Vertonghen will continue at left-back.
Cardiff City v Manchester United (Sun, 4pm)
Key stat: Cardiff have conceded a league-high six goals from outside the box this season.
Robin van Persie has scored in each of his last four Premier League appearances - he last netted in five successive PL appearances back in January 2013.
Striker Andreas Cornelius returns from an ankle injury for Cardiff's Premier League meeting with Manchester United on Sunday.
United pair Michael Carrick and Phil Jones are ruled out by Achilles and groin injuries respectively, while Marouane Fellaini is still handicapped by a wrist problem. Read full Cardiff v Man Utd preview.