Aston Villa v Sunderland
Key stat: Sunderland have won just one and lost 11 of their last 13 Barclays Premier League away games (D1).
Villa trio Gabriel Agbonlahor, Andreas Weimann and Fabian Delph are fully fit again, while Sunderland have Lee Cattermole and Andrea Dossena back from suspension, with Wes Brown available after his red card at Stoke last weekend was overturned. Read full Aston Villa v Sunderland preview.
Cardiff City v Arsenal
Key stat: Cardiff have allowed their opponents more shots on target against them than any other team in the top flight this season (75).
Cardiff could name the same side that held Manchester United last weekend, while Arsenal have Kieran Gibbs available again following illness, with Theo Walcott also in line for a return to the starting line-up. Read full Cardiff v Arsenal preview.
Everton v Stoke City
Key stat: Everton have lost just one of their last 12 Premier League matches (W5 D6 L1) and lost just one of the last 29 at Goodison Park (W19 D9 L1).
Everton boss Roberto Martinez has a decision to make at left-back with Leighton Baines facing six weeks out, while Stoke are without key duo Robert Huth and Marko Arnautovic for the clash at Goodison Park. Read full Everton v Stoke preview.
Norwich City v Crystal Palace
Key stat: Crystal Palace are unbeaten in the last five league meetings with Norwich City (W3 D2 L0), including 2-1 victories in their last two visits to Carrow Road.
Norwich are without a host of players, including Robert Snodgrass, Anthony Pilkington and Alexander Tetty, while new Palace boss Tony Pulis will have to make do without the suspended Yannick Bolasie. Read full Norwich v Crystal Palace preview.
West Ham United v Fulham
Key stat: West Ham are unbeaten in their last eight Premier League games against Fulham at Upton Park (W4 D4).
Ricardo Vaz Te, Andy Carroll and Mladen Petric are among West Ham's absentees for the game, while Fulham are without the suspended Sascha Riether and have doubts over a number of other players. Read full West Ham v Fulham preview.
Newcastle United v West Bromwich Albion, 5.30pm
Key stat: West Brom have won just one of their last eight Premier League away games (W1 D4 L3).
Newcastle have a near full-strength squad to choose from for Saturday evening's game, while West Brom have also benefited from an injury-free week and could name an unchanged line-up. Read full Newcastle v West Brom preview.
Tottenham Hotspur v Manchester United, Sunday 12pm
Key stat: Tottenham Hotspur have won just one of the last 24 Barclays Premier League matches against Manchester United (W1 D6 L17) and none of the last 12 at White Hart Lane (W0 D4 L8).
Christian Eriksen, Danny Rose and Harry Kane are all definite absentees for Spurs, while the potential return of Robin van Persie will leave United boss David Moyes with a dilemma as how best to fit in Shinji Kagawa following his impressive midweek performance. Read full Tottenham v Manchester United preview.
Hull City v Liverpool, Sunday 2.05pm
Key stat: Hull City and Liverpool have met 16 times in all competitions and the Tigers have never won (W0 D4 L12).
Abdoulaye Faye and Alex Bruce are vying to replace the injured Paul McShane in the Hull defence for this one, and whoever starts looks set to avoid meeting Daniel Sturridge, who sustained an ankle injury in training. Jon Flanagan could keep his place at left-back for the visitors. Read full Hull v Liverpool preview.
Chelsea v Southampton, Sunday 4.10pm
Key stat: Chelsea have lost none of their last 15 Premier League games at Stamford Bridge (W12 D3 L0).
Chelsea boss Jose Mourinho is set to make a host of changes to his side following the midweek Champions League defeat to Basel, while Southampton are set to welcome back Dejan Lovren but are unlikely to make too many other changes. Read full Chelsea v Southampton preview.
Manchester City v Swansea City, Sunday 4.10pm
Key stat: Manchester City are the first side to score 26 goals in their opening six top-flight home games of a season since Sunderland (26) in 1935-36.
Vincent Kompany should return for Manchester City, while Swansea are without Wilfried Bony, who picked up an injury in their Europa League defeat to Valencia on Thursday. Read full Manchester City v Swansea preview.