Manchester United v Newcastle United (12.45pm)
Wayne Rooney is suspended following his fifth booking of the season in the defeat by Everton, while Robin van Persie will return from the toe and groin problems which have kept him out since scoring the winner against Arsenal. Javier Hernandez should deputise for the suspended Rooney, with Januzaj in line to start.
Key stat: Jonny Evans has scored in the last two Barclays Premier League meetings between Man Utd and Newcastle and also netted an own goal at Old Trafford in this fixture last season.
Crystal Palace v Cardiff City
Cardiff boss Malky Mackay is confident Craig Bellamy will come back into contention for a trip to London, while Palace have no new problems.
Key stat: This will be the first time Crystal Palace and Cardiff City have met in the top flight of English football.
Liverpool v West Ham United
Key stat: Luis Suarez (13) has scored one more Barclays Premier League goal than West Ham have as a team (12) this season and 10 of Suarez's Premier League goals this season have come at Anfield.
Liverpool will again be without Daniel Sturridge as he recovers from an ankle injury which is set to sideline him until mid-January.
Southampton v Manchester City
Key stat: Southampton have not lost four Barclays Premier Leagues in a row since their first four games of last season.
Victor Wanyama and Nathaniel Clyne have been ruled out of Southampton's game with Manchester City at St Mary's on Saturday. City meanwhile will have captain Vincent Kompany back and fully fit.
Stoke City v Chelsea
Key stat: Demba Ba has scored four Premier League goals against Stoke; only against West Brom (6) has he been more prolific.
Chelsea will be hoping to welcome Samuel Eto'o and Oscar back into their ranks on Saturday, while Stoke have no fresh problems.
West Bromwich Albion v Norwich City
Key stat: Robert Snodgrass opened the scoring in both Barclays Premier League games between Norwich and West Brom last season.
West Brom will be without commanding centre-half Jonas Olsson, while Norwich have no new problems.
Sunderland v Tottenham Hotspur (5.30pm)
Key stat: Sunderland have hit the fewest shots on target this season (33) while Spurs have the lowest shot conversion rate (7%).
Tottenham will be without Jan Vertonghen for the trip to Sunderland, while Jozy Altidore is expected to keep his place in the Black Cats' starting line-up.
Fulham v Aston Villa (Sun, 1.30pm)
Key stat: Fulham have trailed in 11 games this season, more than any other side. They have lost 10 of these matches (D1).
Fulham will be hoping to welcome captain Brede Hangeland back into their ranks, while Ron Vlaar is a major doubt for Villa with a calf strain.
Arsenal v Everton (Sun, 4pm)
Key stat: Howard Webb will officiate Arsenal v Everton on Sunday. The Gunners have won their last eight Premier League games with him as the man in the middle. Arsenal are unbeaten at home in the Premier League with Howard Webb as referee (W10 D4 L0).
Olivier Giroud and Jack Wilshere will be hoping for recalls for the Gunners, while Everton could name the same line-up that defeated Manchester United.
Swansea City v Hull City (Mon, 8pm)
Key stat: Just 10 seasons ago, these sides met in the fourth tier of English football. Leon Britton featured in one of those two games for Swansea. .