Manchester City v Arsenal (Sat, 12.45pm)
Key stat: This match pits the two most clinical teams in the Barclays Premier League with Man City scoring with 20.6% of their shots and Arsenal 18.9%.
Joe Hart looks set to start in goal for Manchester City, while Sergio Aguero, skipper Vincent Kompany and midfield inspiration Yaya Toure are all set to return.
Arsenal will check on the fitness of full-back Bacary Sagna (hamstring).
Cardiff City v West Bromwich Albion
Key stat: Peter Whittingham scored in his last two league appearances against West Brom for Cardiff.
Malky Mackay has just two injury doubts to worry about in left-back Andrew Taylor and experienced forward Craig Bellamy.
For West Brom, striker Nicolas Anelka could be back in contention.
Chelsea v Crystal Palace
Key stat: Chelsea have gained more points (11) from losing positions than any other team in the Barclays Premier League this season.
Chelsea manager Jose Mourinho has pretty much a full-strength squad to pick from, with only long-term absentee Marco van Ginkel set to miss out.
Palace full-back Dean Moxey is a doubt for the trip to Stamford Bridge having been forced off with a hamstring injury during last weekend's win over Cardiff.
Everton v Fulham
Key stat: Everton have kept nine clean sheets in their last 12 league games on home soil.
Everton midfielder James McCarthy is suspended after accumulating five bookings this season, while Tony Hibbert has picked up a slight knee injury in training.
Fulham striker Darren Bent returns after recovering from a slight hamstring problem.
Newcastle United v Southampton
Key stat: Newcastle have won nine and lost none of their last 10 home matches in all competitions against Southampton.
Newcastle will be without Yohan Cabaye due to suspension but Mathieu Debuchy.
Southampton boss Mauricio Pochettino has a number of injury worries, with
Morgan Schneiderlin a doubt.
West Ham United v Sunderland
Key stat: Only Everton (8) have kept more clean sheets in the Premier League than West Ham (7) this season.
West Ham will be without suspended captain Kevin Nolan for the visit of Sunderland, with the Hammers also missing several first-team players through injury.
James Collins and Guy Demel are also struggling due to illness but Sam Allardyce is hoping to have both available alongside James Tomkins and Ravel Morrison, who both return to the squad.
Sunderland boss Gus Poyet has no fresh selection problems ahead of the trip to Upton Park.
Only keeper Keiren Westwood (shoulder) and defender Carlos Cuellar (hip) remain on the casualty list.
Hull City v Stoke City (Sat, 5.30pm)
Key stat: Stoke have committed more fouls than any other team in the top flight (202) this season.
Hull manager Steve Bruce has no new injury concerns ahead of the Saturday Night Football clash.
Sone Aluko (Achilles) and Stephen Quinn (hamstring) are still out but the rest of the Tigers' first-team squad are fit and available.
Stoke goalkeeper Asmir Begovic is doubtful after suffering a thigh injury in training.
Aston Villa v Manchester United (Sun. 1.30pm)
Key stat: Wayne Rooney has scored eight goals in his last 10 Barclays Premier League games against Villa, but they have all come in braces.
Aston Villa will be without Fabian Delph, with Ron Vlaar and Libor Kozak also out.
United will be without van Persie for the next month due to a thigh injury, but they are boosted by the return of Wayne Rooney who is available for selection having served his one-match suspension.
David Moyes has doubts over two defenders, while there are also worries over the fitness of Chris Smalling (hamstring) and Marouane Fellaini (back).
Norwich City v Swansea City (Sun, 1.30pm)
Key stat: There have been 20 goals scored in just four Barclays Premier League meetings between Norwich and Swansea..
Ricky van Wolfswinkel could return to the Norwich squad after a long lay-off with a toe muscle injury.
For Swansea, Angel Rangel could be fit enough to return to the side but Chico Flores misses out.
Tottenham Hotspur v Liverpool (Sun, 4pm)
Key stat: Liverpool have only managed one clean sheet in their last 12 Premier League games, this after keeping four in their previous four PL games.
Danny Rose and Christian Eriksen will be assessed before kick-off, having returned from injury lay-offs in midweek.
Jan Vertonghen is out while Andre Villas-Boas has doubts have a couple of centre-halves.
Second-placed Liverpool will be without Steven Gerrard and Daniel Sturridge but boss Brendan Rodgers should have Jordan Henderson at his disposal.