Mauricio Pochettino's first Premier League game in charge of Tottenham proved memorable as defender Eric Dier grabbed an injury time winner in an incident-packed London derby at West Ham.
The visitors were reduced to 10 men in the 29th minute when Kyle Naughton was sent off for handling a Kevin Nolan shot in the box, but Mark Noble fired the resulting penalty wide.
The Hammers were also reduced to 10 men in the 63rd minute when James Collins was issued his second yellow card, and things got worse for the hosts as Harry Kane sent Dier clear to snatch the winner in added time.
Louis Van Gaal's first competitive match in charge of Manchester United proved one to forget on the other hand, as Swansea stole all three points on the opening day at Old Trafford.
United fans hoped Van Gaal's much-trumpeted arrival would wipe out the misery of David Moyes' ill-fated regime but it proved to be business as usual as Gylfi Sigurdsson steered the Swans to a 2-1 win.
Sigurdsson - making his second debut for the Welshmen - squared for Ki Sung-yueng to open the scoring on 28 minutes but Wayne Rooney pulled United level eight minutes after the break with an overhead kick.
But Garry Monk's men were undaunted and went on to claim the deserved three points when Sigurdsson swept the winner past David De Gea in the 72nd minute.
Alan Irvine looked set for a debut win in charge of West Brom before a late strike from Sebastian Larsson salvaged a point for Sunderland in a feisty 2-2 draw.
Lee Cattermole's thunderous early opener was cancelled out by a Saido Berahino penalty and the Baggies striker put his side in front with a close-range volley in the 74th minute.
But Gus Poyet's men refused to accept defeat and grabbed a point when the impressive Patrick van Aanholt crossed from the left and set up Larsson to stroke home the equaliser.
Substitute Chris Wood gave Leicester something to celebrate on their return to the top-flight as his 86th minute effort sealed a 2-2 draw with Everton.
Aiden McGeady curled the visitors in front on 20 minutes only for Leonardo Ulloa, the Foxes' recent capture from Brighton, to equalise almost immediately.
Steven Naismith slammed Everton back in front on the stroke of half-time but Wood was on hand to hit the leveller past Tim Howard after impressive work from Riyad Mahrez.
Hull keeper Allan McGregor saved a late Charlie Austin penalty as the Tigers hung on for a 1-0 win at QPR.
James Chester put the visitors in front with a diving header in the 52nd minute but his 83rd handball gave the home side their spot-kick chance, only for Austin to see his weak kick well saved.
Andreas Weimann hinted at brighter times ahead for Aston Villa as his 50th minute drive sealed a 1-0 win over Stoke at the Britannia Stadium.
Villa were on top for long periods of the game and could have increased their winning margin with chances for Charles N'Zogbia and Leandro Bacuna.
Premier League results: