The 37-year-old, who is currently playing for Montreal Impact, has decided to hang up his boots when the 2013 Major League Soccer season concludes next week.
The 2006 World Cup winner has confirmed he plans to move into coaching once he finishes playing.
"I want to get into coaching," said Nesta.
"We'll see what level, but I feel that it's something that I can do.
"I plan to rest for a couple of months before learning the trade."
Nesta started his career with his hometown club Lazio before he joined AC Milan in 2002 where he won two UEFA Champions League titles.
The central defender joined Montreal in 2012 and he has made 31 appearances for the Canadian outfit.