Paul Lambert is 9/4 with Sky Bet not to manage another game for Aston Villa after they dropped into the relegation zone with a 1-0 defeat at home to Southampton.
The former Norwich boss is now 4/9 to be the next Premier League manager to leave their post after back-to-back defeats left their Capital One Cup and Premier League survival hopes looking bleak.
With Bradford favourites to make the final after winning their semi-final first leg 3-1 and Villa now odds-on for relegation as they sit third from bottom, the online bookmaker fear for the future of Lambert.
Sky Bet Football Trader Chris Spicer said: "A favourable Capital One Cup draw and a decent run of fixtures in the league gave Villa the perfect chance to make up for their wretched first half of the season, but things have gone from bad to worse with two woeful results.
"While we still expect Lambert to be in charge come next weekend's clash with West Brom, failure to turn their fortunes around soon will surely force the Villa Park board to consider his future."
Meanwhile, victories for Reading, Southampton and Chelsea has seen the odds on their respective managers leaving drift considerably, leaving Alan Pardew as the second favourite to be next to go at 12/1.