Leeds were rewarded for their victory over Tottenham with a trip to Barclays Premier League champions Manchester City.
Neil Warnock's men knocked out Spurs 2-1 at Elland Road to book a trip to the Etihad Stadium in the pick of the ties.
Non-league Luton, who claimed a famous 1-0 win at Norwich on Saturday, missed out on a plum draw with a top Premier League side as they got Millwall at home.
FA Cup fifth round draw:
Huddersfield or Leicester v Wigan
MK Dons v Barnsley
Oldham v Everton
Luton Town v Millwall
Arsenal v Blackburn
Manchester City v Leeds
Manchester United v Reading
Middlesbrough v Brentford or Chelsea
Ties will be played on the weekend of February 16/17.