Manchester United and Manchester City are 5/2 joint favourites for the FA Cup with Sky Bet after a weekend of shocks.
Liverpool and Spurs both bowed out in shock defeats at Oldham and Leeds respectively while holders Chelsea were minutes away from crashing out at Brentford before Fernando Torres goal earned them a replay.
The big guns also avoided each other in the fifth-round draw with Man United taking on Reading at Old Trafford and Man City hosting Leeds.
Sky Bet football trader Joe Petyt said: "All the teams at the top of the betting will be happy with the draw and will be big favourites to progress.
"This means there is a big gap between the front five and the rest but, as we have already seen with Bradford City this week, it's not impossible for an outsider to reach the final. There could be some value out there."