The striker, who scored for Chelsea at St James' Park last season, helped himself to a double as the Reds romped to a stunning 6-0 victory which leaves the Magpies still deep in relegation trouble.
Newcastle were utterly shambolic on a day when they could have all but secured their Barclays Premier League status for another season, and the visitors took full advantage.
Central defender Daniel Agger headed them in front with just five minutes gone and Sunderland old boy Jordan Henderson made it 2-0 12 minutes later.
Pardew threw on substitutes Hatem Ben Arfa and Yoan Gouffran at the break, but it was Sturridge who ended any doubt that that Brendan Rodgers' men would leave north-east with all the points with a double inside six second-half minutes,
Further strikes from substitute Fabio Borini and Henderson rubbed salt into black and white wounds, as did the 75th-minute dismissal of Mathieu Debuchy for a second yellow card.
Spurs took the early lead through PFA Player of the Year nominee Gareth Bale but his score was soon cancelled out by Boyce, before Callum McManaman's firecracker looked to have earned Wigan a vital three points.
However, Boyce's afternoon ended on a sour note when Aaron Lennon's cross rebounded into the net off the Wigan defender's shins, as Roberto Martinez's side saw a vital two points evaporate.
The result means Tottenham missed the chance to move above Chelsea and instead remained in fifth place while Wigan remained in the relegation zone, two points behind Aston Villa, who play Sunderland on Monday.
It had all started so positively for Spurs when Bale pounced in the ninth minute after Latics goalkeeper Joel Robles and defender Maynor Figueroa were too slow in exchanging passes in the box. Robles' clearance was charged down by the Spurs man, who capitalised to give his side the advantage.
However, the lead was short-lived thanks to Boyce, who headed Wigan level two minutes later from Shaun Maloney's corner to leave the sides tied 1-1 at half-time.
Callum McManaman then fired Wigan ahead in the 49th minute with a 25-yard strike which looked to have edged his side out of the relegation zone before Boyce's own-goal.
Aguero swept in a low ball from Samir Nasri for the first before Toure launched a powerful shot past Jussi Jaaskelainen from the edge of the area in the 83rd minute.
The game looked to be done and dusted but West Ham refused to lie down as on-loan Liverpool striker Andy Carroll popped up with a last-minute consolation.
Steven Pienaar gave the Toffees the lead with a 16th-minute strike when he fired home after good work by Seamus Coleman on the byline.
The Baggies claimed an early advantage thanks to Marc-Antoine Fortune. Romelu Lukaku headed in the assist which Fortune bundled over the line in the sixth minute to give the Baggies a 1-0 half-time lead.
Lukaku then claimed a goal of his own after the break, Fortune turning provider, to double the lead, before Fortune and Southampton substitute Gaston Ramirez were both shown straight red cards for violent conduct. Ramirez caught Shane Long with his elbow and Fortune reacted by slapping the Saints midfielder around the head.
Long did not seemed to be too perturbed by the situation as he drilled West Brom's third six minutes later before Southampton ended the game with nine men when Daniel Fox was dismissed for a two-footed challenge on Steven Reid.
Adam, who had not scored in his previous 14 league appearances for the Potters, ended his drought when he lashed Peter Crouch's knock-down into Mark Bunn's net.
The result means Stoke reached the 40-point landmark, while Norwich remained two points adrift in 14th place.