The defender is reaching the end of his 11th campaign with the Old Trafford outfit, having been a Premier League champion six times as well as winning a couple of Champions Leagues and various other trophies.
Now 34, Ferdinand's contract is due to expire at the end of the season and, as yet, he has not decided whether to remain with United,
However, Ferguson is sure he will and believes the former West Ham man has been one of his team's stand-out performers this term.
"Rio Ferdinand has had his best ever season at the club," the manager told MUTV.
"We have had continual problems with the centre-backs being fit.
"Nemanja Vidic has missed half a season, Chris Smalling has missed most of the season, Phil Jones missed a good bit and Jonny Evans missed parts. But Rio has managed his situation very well.
"Although we have left him out of certain games because we have managed him the right way, at the most important times he has been there."
England manager Roy Hodgson is believed to be considering whether to call Ferdinand up for the friendlies against the Republic of Ireland and Brazil at the end of the season.
Ferdinand withdrew from the World Cup qualifiers against San Marino and Montenegro in controversial circumstances in March, citing an "intricate and pre-planned" training regime.
That regime is designed to manage the long-standing back problems that at one stage threatened to bring an early end to his career.
However, Ferdinand has found a way to work round them and Ferguson is convinced he still has much to offer at the highest level, which is why he is sure the defender will turn down lucrative offers from Major League Soccer and the Far East to remain with United.
"I don't think there is any reason to think differently," said Ferguson.
"I hope he will stay and I think he will too."