Press Association Sport revealed on Thursday morning that the forward had asked to leave Loftus Road amid interest from Rangers' Sky Bet Championship rivals Nottingham Forest.
A statement on the west London club's official website, qpr.co.uk, said: "Jamie Mackie has today (Thursday) submitted a transfer request, which the club have reluctantly accepted.
"The 27 year-old has informed the club of his desire to leave, having found first team opportunities limited at Loftus Road in the last six months.
"As previously stated, no player will leave QPR unless the club's valuation is met.
"The club will be making no further comment at this time."