Nemanja Vidic played for an hour as a second-string Manchester United side won 2-0 at Crewe.
The Serbian defender missed United's tour of Australia and the Far East with a back complaint but came through 62 minutes untroubled at Gresty Road.
There were also run-outs for Nani and Antonio Valencia who both missed the trip, with Nani scoring both goals.
The Portugal international, who has been suffering with a broken nose, slotted in a first-half free-kick and then tucked away a second goal after the break.
Nicolas Anelka's impressive pre-season form continued as he scored one of West Brom's goals in a 3-1 win over Atromitos.
The well-traveled Frenchman has now scored three goals for his new club and was joined on the scoresheet by Saido Berahino and Markus Rosenberg.
Thanasis Karagounis had given Atromitis an early lead.
Elsewhere, Maynor Figueroa's goal was enough to give Hull a 1-0 win at Peterborough.