The Capital One Cup produced plenty of shocks last season with League Two Bradford City reaching the final at Wembley and the Bantams' heroics might just inspire one or two more to do the same this time around.
The early rounds have been a graveyard for plenty of Premier League sides over recent years and this week's midweek action is sure to provide some giant-killing with squad rotation the name of the game.
The first fixture which looks to have 'upset potential' sees 14/5 Bristol City host Premier League new boys Crystal Palace.
Neither side have a chalked up a league victory in their respective divisions, but the approach to the game is sure to be very different. Ian Holloway was happy with his side despite their 2-1 weekend defeat at Stoke and he is sure to ring the changes for the trip to Ashton Gate. Several of Palace's summer signings are likely to come into the team such as Neil Alexander, Florian Marange and Elliot Grandin.
Ollie also admitted he desperately needs to bolster his threadbare squad and he'll be viewing the away-day in Bristol as a fixture Palace could do without.
The Robins on the other hand will be looking at a welcome break from League One action, where they have managed just two points this season. They too might well consider making some changes, but frontmen Sam Baldock - who has five goals in five games - and Jay Emmanuel-Thomas are likely to lead the line and they're more than capable of netting against a Palace second string.
Fulham are another team from the top division who might find the going tough on Tuesday.
Martin Jol's men travel to Burton Albion on the back of a 3-1 home defeat to Arsenal and Dutchman has confirmed he will make "a few changes". The Cottagers' recent record in the competition has been woeful and they might well get a shock at the Pirelli Stadium with the 5/1 Brewers ready to pounce.
Gary Rowett is doing a sterling job at the helm of the League Two side, who made the play-offs last season. Rowett's men were fantastic on home soil last term and although they have lost a few key players, they have brought in replacements and the intensity of their play at home might surprise Jol and his changed side.
Finally, another one of the top-flight sides who might struggle to edge past their lower league opponents are Sunderland.
They, like Fulham have an awful record in the competition and face MK Dons - a side they beat away from home last season at the same stage of the competition.
The Black Cats have since had a change of manager and brought in numerous new players, but things are gelling slowly on Wearside and Paolo Di Canio might well be feeling the heat if they slip up against the Dons.
The Dons are 6/1 shots to upset the Black Cats, who are sure to show plenty of changes to the side that earned a 1-1 draw at Southampton - their first point of the season.
Karl Robinson's Dons are sure to be in the right frame of mind and if they can get a goal early on and turn the crowd then they might just chalk up an unlikely victory.
One result will put us in profit for the night, but if you're feeling brave the treble pays almost 160/1.