Roy Hodgson has called Cardiff defender Steven Caulker into his squad for England's World Cup qualifiers with Moldova and Ukraine after Phil Jones and Glen Johnson joined Wayne Rooney in pulling out.
Manchester United manager David Moyes confirmed before the 1-0 defeat at Liverpool that Rooney would miss out after suffering a nasty head wound in training yesterday.
Now it has been confirmed Jones and Johnson will also be unavailable after suffering ankle injuries during the Anfield encounter.
"England have called up Steven Caulker following the withdrawal of three players from Roy Hodgson's squad due to injury," said an FA statement.
Manchester United pair Wayne Rooney and Phil Jones have both left the squad. Glen Johnson, the Liverpool defender, has also withdrawn following his side's win over Manchester United at Anfield."
Caulker has one England cap to his name, having started and scored against Sweden in Stockholm in November 2012.
There is also a doubt over Liverpool match-winner Daniel Sturridge, who confirmed after the game he had been struggling with a groin injury.
It is the kind of scenario Hodgson feared when concern was expressed over such high-profile matches taking place immediately before an international game.
The good news, such as it was, came from Arsenal boss Arsene Wenger, who confirmed the illness that forced Jack Wilshere off in this afternoon's victory over Tottenham at the Emirates Stadium was nothing serious.
"He has a stomach bug," said Wenger.
"It's nothing that will stop him from going to England."