Manchester United have drifted to 8/1 with Sky Bet for the Premier League title after being held to a 1-1 draw by Southampton.
On a day when leaders Arsenal and second-placed Chelsea were 4-1 winners over Norwich and Cardiff respectively, David Moyes' side now find themselves eight points behind the table-topping Gunners.
Robin van Persie's first-half strike looked like it would be enough for the champions but up popped Adam Lallana in the 89th minute to snatch a point for the high-flying Saints.
Eighth-placed United are now just 5/4 to miss out on a top-four place.
Arsenal moved clear at the top as Jack Wilshere scored a contender for goal of the season in their comfortable victory over the Canaries.
Arsene Wenger's men, who are now 9/2 with Sky Bet for the title, capitalised on Liverpool's draw at Newcastle in the lunchtime kick-off thanks to goals from Wilshere, Aaron Ramsey and a Mesut Ozil brace.
Meanwhile Chelsea are 5/2 second favourites after a Eden Hazard brace and further strikes from Oscar and Samuel Eto'o saw them breeze past Cardiff.
Manchester City remain favourites for the title at 15/8 after a 3-1 victory at West Ham on Saturday evening.
At the other end of the table, Sunderland remain bottom of the pile with one point from eight games as they started the Gus Poyet era with a 4-0 defeat at Swansea.
Poyet's side are odds on at 8/11 for the drop, with Crystal Palace just 2/11 for relegation after losing six of their first seven games.
Cardiff and Hull are next in the betting at 2/1 and 9/4, with Norwich 11/4 and Fulham 10/3.