Only Benfica's 1-1 draw with Olympiakos prevented a clean sweep as Manchester United, Manchester City, Real Madrid, Bayer Leverkusen, Galatasaray, Paris St Germain and Bayern Munich all registered victories.
Sky Bet's Head of Trading Sandro di Michele said: "A bad night at the office with both Manchester clubs scraping wins as well as PSG and Bayern thumping their opponents.
"Zlatan Ibrahimovic and Cristiano Ronaldo scoring didn't help matters as they were popular with the anytime and first goalscorer punters too.
"Our saving graces were Wayne Rooney hitting the post instead of opening the scoring and the Benfica game ending in a draw - much to the annoyance of some of our punters who wanted the game called off due to heavy rain!"
Sky Bet make Bayern Munich their 11/4 favourites for the Champions League following Matchday Three, with Manchester City 14/1 and Manchester United 16/1.