David Moyes' difficult start as Manchester United manager turned into a full-blown crisis as Yohan Cabaye ended Newcastle's 41-year wait for an Old Trafford win by scoring the only goal in a 1-0 victory.
The result condemned United to back-to-back home Premier League defeats for the first time 2002.
It meant United have lost five times already this season and that they have collected just two points from their last four games.
Little wonder the reaction at the end was one of anger from the home supporters, who watched virtually the same group of players they booed off today clinch a 20th title by 11 points less than seven months ago.
The on-loan Liverpool winger came on as a substitute six minutes from time and his first real contribution was to pick the ball up on the left, cut inside and unleash a ferocious shot into the top corner to seal a 3-2 triumph.
Jose Mourinho's first trip to the Britannia Stadium began well as Andre Schurrle gave Chelsea a 10th-minute lead.
But Peter Crouch levelled three minutes before half-time, and five minutes after the break Stephen Ireland put the hosts ahead.
Schurrle quickly equalised with another fine finish and it looked like both sides would have to settle for a point until Assaidi's brilliant intervention earned a 3-2 victory.
Stoke's last win over Chelsea came in the League Cup in 1995 when Potters manager Mark Hughes was in the Blues side, while their most recent league victory was in 1975.
It was the Uruguay international's shot which produced Guy Demel's own goal just before half-time, he won the free-kick from which Mamadou Sakho scored his first goal for the club and then added a late goal to calm the nerves after Martin Skrtel put past his own goalkeeper.
He might even have laid claim to the fifth goal of the afternoon but the ball had taken a fateful deflection off Joey O'Brien.
Suarez could have had back-to-back hat-tricks after getting four in midweek against Norwich but in taking his tally to 26 in his last 25 league matches, including 10 in his last four home matches, he provided further proof - should it be needed - that he is central to the Reds' bid to regain Champions League status.
As impressive as City have been since Manuel Pellegrini's arrival, they have shown a soft underbelly away from home, winning just two matches on the road - the latest of which came at West Brom on Wednesday.
It was a result they were unable to match on the south coast, where Osvaldo's wondrous goal earned Southampton a deserved, morale-boosting point.
Adam Johnson gave the hosts a 37th-minute lead only for Paulinho to level the scores just before the break.
Tottenham edged ahead thanks to a John O'Shea own goal five minutes into the second half and held on for a second successive victory.
The former Stoke boss took charge at Palace a little over two weeks ago and, following a narrow loss at Norwich, the Welshman has now guided the Eagles to back-to-back home wins as Cameron Jerome and Marouane Chamakh got on the scoresheet to secure a comfortable triumph.
Hooper scored the opener in the 13th minute, smashing an unstoppable drive into the top corner, before Fer finished off a sharp counter late on to seal the points.
West Brom had countless chances to take at least a point from this game with Stephane Sessegnon twice failing to convert great opportunities and Shane Long also guilty of being profligate in front of goal.
It is now one win in nine games for the Baggies, and Steve Clarke's side were booed off at full-time.