Tottenham's Andre Villas-Boas is 2/5 with Sky Bet to be the next Premier League manager to leave his position.
The Portuguese boss watched his side thrashed at home 5-0 by Liverpool in a hugely one-sided contest - Spurs did not even manage a shot on target.
Villas-Boas is the clear market leader in the betting ahead of 8/1 chance Sam Allardyce at West Ham and Cardiff's Malky Mackay at 10/1.
Sky Bet's Head of Trading Sandro Di Michele said: "Tottenham were all over the place against Liverpool.
"This was their worst home result for many years and punters clearly think that time is getting short for AVB to sort out the situation."
Liverpool are up to second in the table and 13/2 with Sky Bet to take the title while Manchester United boosted their prospects with a 3-0 success over Aston Villa and trade at 20/1.
Manchester City are favourites at 6/5.