Leicester took advantage of Burnley's surprise defeat at Middlesbrough to sneak top of the Sky Bet Championship as QPR slipped up at Nottingham Forest.
Emmanuel Ledesma's strike condemned Burnley to defeat at the Riverside Stadium, allowing Leicester to steal their perch.
QPR could have swiped first place for themselves with a win at Forest, but Harry Redknapp's side were undone by goals either side of half time from Greg Halford and Andy Reid.
Fourth-placed Derby were left to rue Chris Martin's missed penalty as Huddersfield snatched a 1-1 draw.
Craig Bryson handed the visitors a 1-0 lead, three minutes after Martin failed to convert that spot-kick.
But with four minutes remaining Martin Paterson fired into the roof of the net to steal a share of the spoils for Huddersfield, denying Derby the opportunity to go level on points with Burnley.
Tom Ince plundered an equaliser to hand Blackpool a 1-1 home draw against Leeds, frustrating the visitors who had taken a first-half lead through Lee Peltier.
Blackpool had Kirk Broadfoot sent off for violent conduct late on, but still managed the draw.
David McGoldrick's brace took his season's tally to 11 and helped Ipswich claim a 3-0 win at Doncaster, with Luke Chambers netting in between times.
Lawrie Wilson's brace and a goal for Yann Kermorgant sealed struggling Charlton's 3-2 home victory over Brighton.
Charlton fended off two goals from Jose Ulloa to claim a victory to ease relegation fears.
Blackburn failed to find a way to break down stubborn Sheffield Wednesday at Ewood Park, the relegation-battling visitors pleased to leave with a 0-0 draw.
New manager Guiseppe Sannino led Watford to their first league victory in 11 matches, a resounding 4-0 thumping of Millwall.
Troy Deeney converted a penalty after Danny Shittu was sent off for the foul that brought the spot-kick.
Fernando Forestieri, Ikechi Anya and Lewis McGugan added the other goals, the latter also from the spot, that kickstarted life after Gianfranco Zola for the Hornets.
Millwall later sacked manager Steve Lomas as a direct result of the heavy defeat at Vicarage Road.
Jesse Lingard was sent off as Wigan and Birmingham played out a 0-0 draw at the DW Stadium.
Matt Ritchie scored twice as Bournemouth condemned lowly Yeovil to a comprehensive 3-0 defeat on the south coast, the other goal coming from Eunan O'Kane.
Neil Danns' second-half goal claimed a 1-0 victory for Bolton at Barnsley.