Sky Bet make Manchester United a 25/1 shot to retain the Barclays Premier League title after the 2-1 defeat to Tottenham on New Year's Day.
The Red Devils now sit in seventh with an 11-point gap to make up to leaders Arsenal, who left it late to start 2014 with a 2-0 victory over Cardiff.
Manchester City remain one point behind the Gunners after winning 3-2 at Swansea but head Sky Bet's title betting as odds-on favourites at 10/11.
Chelsea (7/2), Liverpool (8/1), Tottenham (50/1) and Everton (66/1) are the other teams between United and the summit.
Spurs have been cut to 3/1 for a top-four finish after winning at Old Trafford.
City, Chelsea, Arsenal and Liverpool are all odds-on in that market with Sky Bet.
West Ham can be backed at 13/8 to go down with Sky Bet after they lost 2-1 at Fulham, who are now 15/8 in the relegation market.
Sunderland are into 4/6 after they lost 1-0 at home to Aston Villa, who can be backed at 8/1, while Crystal Palace's draw with Norwich saw those sides trimmed to 4/7 and 11/4 respectively.
Cardiff are 11/8 having played well in defeat at Arsenal.
It was also a busy day in the Sky Bet Football League.
Championship leaders Leicester won 3-1 at Millwall and head the title betting at 11/8.
QPR (2/1), Derby (9/2) and Burnley (10/1) are the clubs putting the pressure on.
Brentford sit at the top of League 1 but it's second-placed Wolves who head the title market at 6/5 with the Bees available to back at 7/4.
In League 2, Chesterfield remain 9/4 favourites but Scunthorpe are now top of the table after beating Rochdale and move to 100/30 in the betting to finish the campaign on top.