Jose Mourinho lost his unbeaten record at Stamford Bridge as his side were stunned by the bottom club 2-1 and are now out 20/1 as they sit two points behind Liverpool.
The latter face Norwich at midday on Sunday and would stride five points clear while Manchester City are 7/2 chances ahead of their game on Monday at home to West Brom.
Sunderland have enjoyed a good week following their draw at Manchester City as well and have eased to 8/11 with Sky Bet for relegation.
Cardiff are 1/6 in that market following their 1-1 draw at home with Stoke.
It was a good day for Brighton in the Sky Bet Championship, with some of their rivals dropping points. They shorten to 7/1 from 8/1 without taking the field in Sky Bet's promotion betting.
The markets now see pre-season favourites QPR as the third most likely team to win the play-offs, with Wigan and Derby both 12/5 to be promoted and QPR back to 3/1 from 5/2.
At the bottom of the Championship it was a bitter blow for Barnsley as they lost to Yorkshire rivals Leeds.
Barnsley have been plunged back into deep trouble and are 1/8 for the drop. Their woe was enhanced by Millwall battling to a win against recent form team Middlesbrough. Millwall are now out to 11/4 to be relegated.