Manchester United striker Danny Welbeck seems certain to miss England's friendlies against Chile and Germany later this month.
Welbeck has not figured since the draw against Southampton on October 19, since when he has been sidelined with fluid on his knee.
United manager David Moyes has already ruled the 22-year-old out of Sunday's showdown with Arsenal at Old Trafford.
Although Welbeck was selected on Thursday as part of Roy Hodgson's squad for the start of England's World Cup build-up, Press Association Sport understands there is little chance of him being involved.
"The only one who is not in contention for Sunday is Danny Welbeck," said Moyes.
"He is still suffering with his knee."
England play Chile on November 15 and Germany on November 19, with both games at Wembley.
Meanwhile, Darren Fletcher completed the first full 90 minutes of his comeback in United's 1-0 Under-21 defeat by Stoke on Friday.
Fletcher is fighting his way back to fitness after being laid low by a chronic bowel complaint.
Although the Scot is still believed to be some way short of a return to first team duty, manager David Moyes was on hand to watch the majority of a game that was switched to United's AON Training Complex at short notice.
Fletcher came through the contest - which also featured Fabio and Wilfried Zaha - unscathed, although striker Will Keane lasted only a couple of minutes after suffering a nasty cut to his head.