The Colombian midfielder is said to be a transfer target for clubs across Europe ahead of the re-opening of the transfer window.
Spurs are reported to have been following the 26-year-old for some time, and could be set to make their move this summer.
Inter would be reluctant to part with a man who has become a regular in their side since completing a permanent switch from Porto in 2012, but concede that interest in his services is building.
Moratti said: "Guarin? He is a really good player and for that reason he is liked by others.
"Tottenham are really interested."
While Spurs are among those plotting a summer raid, ambitious Russian outfit Anzhi Makhachkala have moved to distance themselves from reports suggesting they are planning an approach.
A statement on the club's official website read: "Regarding the rumours on Fredy Guarin, we deny holding an interest in the player.
"These assumptions are without substance, as they also are about (Roberto) Soldado and (Pierre-Emerick) Aubameyang.
"The Anzhi name is used to fuel talks and increase a player's value. There aren't any negotiations under way."