The Dutch defender is struggling with a calf problem and looks likely to miss out.
The defender was suspended for Saturday’s 1-0 defeat at Newcastle and could sit out again with an injury as boss Tim Sherwood rates him touch and go.
Kieran Richardson and Philippe Senderos are sidelined with Aly Cissokho and Alan Hutton remains a doubt for Sherwood’s strugglers.
West Brom strike pair Saido Berahino and Brown Ideye are both doubtful for the game.
The in-form duo may join fellow forward Victor Anichebe (hamstring) on the sidelines, with Berahino struggling with a knock and Ideye has had a scan on a knee problem suffered in Saturday’s 1-0 win over Southampton.
Head coach Tony Pulis reported no other issues ahead of the Premier League fixture.