The league leaders go into the encounter at the Nou Camp on the back of last weekend’s 2-0 triumph at city rivals Espanyol.
The result kept Barca two points clear of Real Madrid with five games remaining.
“The three points against Espanyol were vital in what was a special game,” Luis Enrique said to the Spanish press.
“But Real Madrid are close to us and we need to keep winning games. I am convinced that we need the three points tomorrow in order to aspire to the title.”
Getafe held Barca to a goalless result back in December and also frustrated the Catalan giants last season, drawing 2-2 at the Nou Camp.
“We are taking this game against Getafe very seriously,” Luis Enrique added. “Getafe are a difficult rival and even though they are without several players, they will pose problems for us.
“But I see my players very motivated.”
Barca, who have lost just two of their 16 league games at the Nou Camp this season, are without the services of Spanish left-back Jordi Alba, who must serve a one-match ban.
However, Thomas Vermaelen has returned to full fitness and could make his first appearance for the club nearly nine months since joing from Arsenal.
Getafe travel to Barcelona without midfielders Pablo Sarabia and Diego Castro, both out injured. However, defenders Alexis Ruano and Emiliano Velazquez return from suspension.
Pablo Franco’s side, who are seven ponts clear if the relegation zone, followed their 4-0 defeat at Athletic Bilbao with a 1-0 home loss to Levante on Saturday and they a still not certain of being in the top-flight next season.
“It is taking us longer than we thought,” Franco said.
“But we are convinced we will achieve our aim very soon. Our defeat to Levante was a big blow for us but we are looking ahead.
“We’ve had very little time to prepare for this game. Barca are a fantastic team and are on an extraordinary run of form, perhaps their best of the season. But we will go there ready to compete and looking to make life difficult for them.”
Watch Barcelona v Getafe live on Sky Sports 5 from 6.55pm on Tuesday.