The Robins have shipped six goals in their opening three games in all competitions this season and are struggling to find a settled line-up at the back following skipper Gordon Greer’s move to Brighton in the summer.
Morrison, 19, could replace Lescinel Jean-Francois or Scott Cuthbert at the heart of an inexperienced Robins defence.
“This could be the time when Sean can throw a few markers down for himself,” Wilson told BBC Wiltshire.
“After us conceding goals I think anybody would say ‘right, I’m going to roll my sleeves up now and make the manager take notice, I want to be in in contention for Saturday’.”
Goalkeeper David Lucas shook off a thigh strain to face Hartlepool last week and will retain his place between the posts, while striker Vincent Pericard is available after recovering from a bruised knee.