There were tributes to Sir Jack, who died on Tuesday at the age of 91, before the match as his name was spelt out in the stands.
But the emotion of the occasion initially seemed to get the better of the Wolves players, who only really hit their stride in the final third of the match, with Edwards breaking the deadlock in the 85th minute and Afobe sealing the win four minutes later with a debut strike following his arrival from Arsenal last week.
It was tough on bottom-of-the-table Blackpool, who remain without an away win this season. They had looked set to hold on for a priceless point before Wolves’ late show.
Promotion chasing Wolves, who have now won five of their last six league games, had toiled to try to break down Lee Clark’s well drilled Blackpool side.
It took 30 minutes for the game to come to life and when it did it was Blackpool who initially threatened with Andrea Orlandi and Steven Davies being denied by goalkeeper Carl Ikeme.
But Wolves should really have taken the initiative, and the lead into half-time, when Wales international Edwards was presented with a gilt-edged chance.
Edwards, who was on target twice in Tuesday’s FA Cup tie against Fulham, was released by a through ball from Nouha Dicko.
Edwards raced beyond the Blackpool defence and surged into the penalty area where he only had goalkeeper Joe Lewis to beat. But Lewis successfully narrowed the angle and Edwards pulled a low and weak shot wide of the far post.
The clash marked the return to Molineux of Blackpool’s former Wolves midfielder Jamie O’Hara. His spell at Molineux had turned sour and he was roundly jeered every time that he touched the ball.
But that just seemed to fire him up and a determined performance from O’Hara eventually saw him booked for a heavy 59th-minute challenge on Edwards.
Wolves introduced Afobe from the bench to try and pep up their attack and he formed a fresh front-line with Nouha Dicko.
But a Blackpool defence that was inspired by Peter Clarke proved to be a tough nut to crack.
When Wolves did find a way through Lewis frustrated them – denying Rajiv Van La Parra at his near post in the 74th minute after a neat pass from Kevin McDonald.
That sparked a spell of intense Wolves pressure and Blackpool finally cracked when Edwards bundled home Van La Parra’s right-wing cross.
The win was assured after Lewis and Blackpool substitute Darren O’Dea got into a terrible muddle trying to cut out a pass from McDonald and Afobe was able to walk the ball into an empty net.