First-half goals from Billy McKay and Ryan Christie were enough for Inverness, who created plenty of opportunities and were good value for the three points, while Hamilton were left to rue a pair of costly errors.
The visitors started brightly on the artificial surface at New Douglas Park but Christie shot wide after being played in by McKay.
And Inverness duly took the lead in the 10th minute when McKay latched onto a poor back pass from Michael Devlin and lifted the ball over the advancing Michael McGovern.
They almost added a second goal minutes later, but McGovern pulled off a fine save to keep out a powerful Christie effort.
Hamilton tried to hit back and player-manager Alex Neil was not far off target with a glancing header from a Danny Redmond free-kick.
But Hamilton then made another key error, Louis Longridge ceding possession in midfield to Danny Williams and, though McGovern did really well to save from the Inverness man, Christie (25) was on hand to slot home the rebound at the back post.
Hamilton were undaunted and enjoyed a good spell in the run up to half-time, only to be denied by Dean Brill, who produced a fine save to keep out a Longridge curler.
The hosts continued to press after the break and Imrie arrived at the back post to get on the end of a cross but his header was straight at Brill.
Inverness were still a threat at the other end and Josh Meekings headed wide from a corner before Greg Tansey’s shot from just outside the area was well saved by McGovern, who then pulled off another good stop to deny McKay.
Hamilton’s desperate pleas for a penalty when the ball hit Meekings on the arm were waved away and sub Mickael Antoine-Curier had a shot blocked by Brill minutes after coming off the bench.
Another sub almost made a quick impact at the other end, Marley Watkins of Inverness smashing a shot against the crossbar moments after entering the fray.
Watkins looked extremely lively after coming on and he drew another good save from the busy McGovern, after good work from Christie and Aaron Doran, as Inverness cruised to a comfortable opening day success.