Head coach Robbie Neilson is set to freshen up his team following last Sunday’s defeat in the Edinburgh derby.
Billy King and Neil Alexander join Prince Buaben and Dale Carrick on the sidelines after undergoing minor surgery, while Adam Eckersley is suspended.
Neilson said: “I’ll make some changes from last weekend to get some players game time.”
The champions, who have carried all before them in their relentless drive to the title, have an impressive home record, with just four points dropped from 16 games, scoring 53 goals in the process and conceding nine.
Hearts are unbeaten against them in 15 league and cup matches; Raith’s last win over the Edinburgh side was a 1-0 victory at Tynecastle 22 years ago, Davie Sinclair scoring the winner.