Alex Bruce looks unlikely to be involved when Hull begin their Championship campaign at home to Huddersfield.
Bruce, son of Tigers boss Steve, has been nursing an Achilles injury and he will probably run out of time to prove his fitness ahead of Saturday’s opener.
However, fellow defender Harry Maguire is fit and will be included in the squad after recovering from a ankle problem.
Ryan Taylor, Sam Clucas, Isaac Hayden and Chuba Akpom have recently been added to the ranks and all four players could make their debuts for the club against the Terriers.
Huddersfield boss Chris Powell is hoping to select his starting line-up from a fully-fit squad.
Strikers Ishmael Miller and James Vaughan have both had a disrupted pre-season and have missed game-time due to niggling injuries, but are expected to be included in Powell’s squad.
Midfielder Jonathan Hogg has also missed part of pre-season through injury, but returned to play the second half of the recent friendly defeat at Barnsley.
Summer signings Dean Whitehead, Jason Davidson, Kyle Dempsey, Jordy Hiwula and Martin Cranie are all in contention to make their competitive debuts for the club.
Relegated Hull are odds-on favourites (8/11) with Football League sponsors Sky Bet ahead of their clash with Huddersfield at the KC Stadium.
The away side, who finished 16th in the second tier of English football last season and suffered a heavy 4-0 defeat at the hands of Bournemouth on the opening day 12 months ago, are 4/1 to start their new campaign with all three points.
There is a three-way tie at the top of the first goalscorer market, with Hull’s Chuba Akpom, Nikica Jelavic and Dame N’doye all 9/2, while the Tigers to win and over 2.5 goals to be scored in the match is a 7/4 chance.