Manchester United remain without the suspended Marouane Fellaini, injured Phil Jones, who has thrombosis, and Marcos Rojo, who is lacking match fitness, but Bastian Schweinsteiger could make his first start for the club.
Newcastle, meanwhile, are likely to hand a debut to new signing Florian Thauvin but are without Daryl Janmaat after he was sent off against Swansea last weekend.
Moussa Sissoko should be fit for the game at Old Trafford, which kicks off at 12.45pm.
Manchester United have won five of their last six Premier League clashes with Newcastle (L1) and have lost just two of their last 25 top-tier encounters with the Magpies (W18 D5).
Newcastle have only ever enjoyed one Premier League victory at Old Trafford in their 21 visits, with that 1-0 win coming in December 2013 (D7 L13).
The Magpies have managed just two goals in total in their last four league encounters with the Red Devils.
Newcastle have lost more Premier League games against Manchester United than any other side (25).
The Red Devils have won 15 of their last 19 Premier League games at Old Trafford.
Newcastle have lost seven consecutive Premier League away games, equalling their record from October 1999.
The Magpies haven’t lost eight successive league games away from home since a run of nine away losses in October 1977.
Wayne Rooney has scored 12 goals and assisted seven more in 20 Premier League appearances against Newcastle.
Rooney has netted only four goals, provided one assist and attempted just 14 shots on target in 20 Premier League games in 2015 so far. In 2014, he scored 16 goals and assisted five more in 28 PL apps.
Morgan Schneiderlin has run further than any other United player in both of their Premier League games so far in 2015-16 (7.7 miles v Spurs, 8.1 miles v Aston Villa).
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