MK Dons manager Karl Robinson is expected to make a host of changes for the fixture.
Stephen Gleeson will be rested while fellow midfielder Darren Potter and defender Dean Lewington are nursing knocks.
Defender Mark Beevers is unavailable under the terms of his loan from Sheffield Wednesday and Adam Smith (England Under-21s), Ian McLoughlin (Republic of Ireland Under-21s) and Gary MacKenzie (Scotland) are all on international duty.
Tom Flanagan, George Baldock and Adam Chicksen are all expected to be involved, while Robinson could include three teenagers in the squad.
Leon Lobjoit, 17, George Williams, 16, and Brendan Galloway and Dele Alli, who are both 15 years old, have been given squad numbers for the first-round tie.