Morecambe boss Jim Bentley is set to be without striker Danny Carlton.
Carlton was stretchered off during the 1-1 draw at Torquay on Saturday and likely to be sidelined on Tuesday.
Izak Reid replaced Carlton at the weekend and is pushing for a start, while Phil Jevons could also come into contention after also featuring as a subsitute following his calf injury.
Skipper Will Haining returned from injury to play the final few minutes against Torquay and will also be pushing for a return to the side.
Midfielder Gary McDonald (knee) and striker Lewis Alessandra remain doubtful while defender Paul Scott is still recovering from knee surgery.
Preston boss Phil Brown is likely to rotate his side for the visit.
Competition rules limit clubs making wholesale changes but Brown is expected to give some players on the fringe of the first-team some much-needed game time.
That could mean starts for midfielder Ian Ashbee and striker Juvhel Tsoumou, while goalkeeper Iain Turner will be hoping to dislodge young stopper Andreas Arestidou.
Keammar Daley expected to play before linking up with the Jamaica squad but striker Iain Hume has already flown out to join up with the Canada squad ahead of their World Cup qualifying matches with St Lucia and Puerto Rico.
Brown will be looking for a reaction from his side after their seven-match winning streak in League One came to an end with defeat to Leyton Orient on Saturday.