Jose Mourinho has ruled out Luke Shaw, Marcos Rojo and Ashley Young from playing in the first month of the season.
Rojo, Shaw and Young are continuing rehabilitation from injury in the USA, but will not play a part in any of the games on tour.
Mourinho believes that Shaw will be the first to return, but that Rojo might even be out until 2018.
“No chance for the beginning of the Premier League,” Mourinho said.
“Luke Shaw is the first one to recover, Marcos will be the last one and Ashley in between.
“I would say Luke September, Young October, Marcos December, even January.
“But it’s good to have them, it’s good for them to be with us, it is good for them to recover with the group.
“I have to say the group is really strong, really together and for them important for them to be with us and not in Manchester working alone.”