Wilfried Zaha is facing four weeks on the sidelines with an injury sustained in the opening-day defeat to Huddersfield.
The Palace attacker left Selhurst Park on Saturday with his right knee in a brace following the 3-0 loss to the Premier League new boys.
The Guardian are reporting that Palace expect to be without Zaha for four weeks after tests showed ‘minor damage’ was more serious that it was first thought.
Such a lay-off would see Zaha miss Saturday’s trip to Liverpool as well as home games with Swansea in the Premier League and Ipswich in the League Cup.
The 24-year-old would also miss Ivory Coast’s World Cup qualifying double-header with Gabon on September 2 and 5.
Palace are hoping to have Zaha back for the Premier League clash with Burnley on September 10.
Zaha signed a new five-year contract this summer, despite interest from Tottenham. His absence will come as a major blow to new Palace boss Frank de Boer, who was already light on attacking options.