Keith Hill has no injury or suspension concerns but may shuffle his pack.
Dale, promoted from League Two only last May, have lost four of their last five games to disappointingly slip to eighth in the table – six points adrift of the top six with two games remaining.
Their play-off hopes are effectively over, but Hill is looking for his men to bow out at Spotland on a high in their final home game of the season.
During the 3-1 defeat to Charlton on Easter Monday, Brian Barry-Murphy and Will Atkinson replaced Matt Done and Nicky Adams respectively.
Done, Adams and striker Jean-Louis Akpa Akpro could earn starting roles.
Darren Ferguson could recall a host of first-team players.
Ferguson made seven changes for the 2-2 draw with Yeovil on Monday to rest some tired legs but is likely to bring the likes of Craig Mackail-Smith, George Boyd, Joe Lewis, Grant McCann and Ryan Bennett back into the side.
Posh have already booked their place in the play-offs but will be looking for two more wins to secure home advantage in the second leg.
Right-back Mark Little is out with his ankle problem and left-back Grant Basey is likely to be missing for a couple of weeks with a knee injury.
Former Dale full-back Tom Kennedy only has a slight chance of being involved in the play-offs after damaging his knee ligaments in the recent win at Dagenham.