Rotherham have been rocked by the absence of Mark Randall for the home game with Macclesfield.
The midfielder, on loan from Arsenal, only lasted 20 minutes of his debut at Southend on Saturday before breaking his collarbone and he now faces up to eight weeks on the sidelines.
Defender Exodus Geohaghon has returned to Peterborough following the completion of his three-month loan spell but skipper Ryan Cresswell has recovered from a back injury that has kept him out of the last two games and he will return to the side.
Manager Ronnie Moore was incensed at the performance of his side as they slumped to defeat in Essex and has promised changes.
Ryan Taylor should retain his position in attack but Marcus Marshall, Danny Harrison, Luke Ashworth and Mark Bradley will all be in with a shout for a starting berth.
Macclesfield manager Gary Simpson again has a number of injury absentees ahead of the trip to Rotherham.
Striker Emile Sinclair and defender Paul Morgan have hamstring problems, midfielder Richard Butcher still has a knee injury and Shaun Brisley is out with a hip problem.
However, forward Ricky Sappleton was on the bench at the weekend for the first time after his split knee-cap last season.
Simpson has no other major injury or suspension concerns as his side seek to build on Saturday’s 2-1 home win over Burton.
Brewers boss Paul Peschisolido accused the Silkmen of being a long-ball team after the game but Simpson retorted: “I’m pleased that he thinks we’re a difficult place to come because I want people to be worried and thinking this is a hard place to come.”