Robins saw goalkeeper Luke Daniels banned for three games after being dismissed for violent conduct during Saturday’s season-opening 2-1 defeat at League One newcomers Burton.
And to make matters worse for the Iron, Luke Williams and Niall Canavan have both been ruled out for over a month following first-half injuries at the Pirelli Stadium.
Joe Anyon came on between the sticks and looks set to continue, although the Iron have swooped in for Hull City shot stopper Rory Watson who joins on a 28-day emergency loan.
Barnsley head coach Lee Johnson will monitor teenage defender James Bree, who missed the opening-day defeat at Chesterfield due to a groin injury.
Summer signing Ryan Williams is struggling with a similar problem after playing no part at the weekend and also remains doubtful.
Johnson could hand starts to two summer signings, striker Marley Watkins and midfielder Joe Rothwell, who stepped off the substitutes’ bench on Saturday, while recent loan signing Nick Townsend, is hoping to feature in goal.
Defender Mason Holgate was no included in Johnson’s squad at the weekend, fuelling speculation that he is poised to complete a move to Manchester United.