Southend will be able to welcome back Bilel Mohsni when Rotherham travel to Roots Hall.
The centre-half has served a three-match ban following his dismissal at Barnet and comes into contention for a start.
Midfielder Craig Easton has suffered a setback in his quest for fitness following a calf injury and looks set to miss out on the visit of Ronnie Moore’s men.
Waide Fairhurst is struggling with a back injury and Adam Bouzid has returned to France to rest following surgery to his skull. The midfielder suffered from a clash of heads in a recent reserve fixture and could be out for two months.
Sofienne Zaaboub could hand boss Paul Sturrock some better news as he looks set to return after missing the 1-0 defeat at Bury with a groin injury.
Strikers Barry Corr and Blair Sturrock returned in that game at Gigg Lane after recent knocks, and having come through unscathed, they should again lead the Shrimps line.
Rotherham skipper Ryan Cresswell is a doubt for the long trip to Southend.
The centre-half suffered a back injury in the warm-up to last weekend’s 4-3 home defeat to Wycombe and has yet to return to training.
Luke Ashworth received a last-minute call-up to replace Cresswell, though Nick Fenton returned to reserves action in midweek after a recent calf injury and could come into the side.
Fellow defender Exodus Geohaghon plays the final game of his three-month loan spell from Peterborough, with boss Ronnie Moore keen to bring him back in January.
On-loan Arsenal midfielder Mark Randall is set for his debut in midfield after joining the Millers, while Ryan Taylor continues to push for a start in attack.
Dale Tonge remains a long-term absentee with a metatarsal injury.