The in-form Liverpool frontman injured a thigh in training at St George’s Park on Friday and has not travelled with Roy Hodgson’s squad.
An FA spokesman said: “Daniel Sturridge has had a scan and will now return to Liverpool FC for treatment. He will play no part in the forthcoming Switzerland match.”
Sturridge, who has scored five goals in 16 internationals, revealed his despair on Twitter: “Heartbroken soul right now. Nothing worse than being injured,” he tweeted.
Hodgson has not called up a replacement, so he will pick from captain Wayne Rooney, Rickie Lambert and Danny Welbeck in attack, with the latter likely to get the nod alongside Rooney.
Apart from that enforced change it attack, Hodgson is not expected to make too many alterations from the side that defeated Norway 1-0 in a friendly at Wembley on Wednesday night.
Centre-back Gary Cahill missed training on Friday with an ankle problem, but is expected to be fit.