West Brom duo McAuley and Brunt have been key figures for manager Michael O'Neill but will not feature in Adana.
Both men played the full 90 minutes of Albion's dramatic 2-2 draw with Chelsea on Saturday, but Brunt has withdrawn with groin and knee problems and McAulely misses out for unspecified personal reasons.
The further absence of nine-cap Rotherham midfielder O'Connor, who has a thigh injury, leaves O'Neill with just 18 players at his disposal.
No replacements have been announced at this stage, but such a paucity of numbers makes it probable that the likes of Barnsley winger Paddy McCourt could be called up to cover for Brunt, with Hull City defender Alex Bruce a possible replacement for McAuley.
O'Neill would be loath to draw on the country's U21 squad for reinforcements given that they have a European Championship qualifier in Italy on Thursday night.