The former Stoke boss has guided Palace to two Premier League wins in three home games since he succeeded Ian Holloway in November, and another would lift them above Chris Hughton's side and further clear of the drop zone.
The Eagles were gallant in a 1-0 defeat to free-scoring Manchester City on Saturday, and although Pulis is attaching no extra importance to the clash with Norwich, he believes his side will be the outsiders in most of their remaining fixtures.
When asked if Wednesday's game was more significant in their relegation battle, Pulis said: "They are all worth three points.
"The Man City game has gone now so the next big game is Norwich. Every game is a cup final for us in the Premier League. We played well at Chelsea and didn't get anything, we played really well at Man City and picked no points up.
"All that we did is brilliant for confidence and everything else and gives the players a lift to go out and compete with top-class players.
"The bottom line is when it comes to Wednesday we are playing another team who have more experience than us in the Premier League and have had more years to bed down.
"We will be the underdogs again, we are the underdogs most weeks and we just have to accept that."
Pulis is expecting a tough test against the Canaries, and warned Palace fans to temper their expecatations despite the encouraging performances in the narrow away defeats to Chelsea and Manchester City.
"That (expectation) is something you have to deal with," he added.
"The players have to deal with that, there is no hiding the fact that we are playing at home and we need to win home games. We are hoping that we get some points.
"Norwich are one of the teams in the bottom half of the table who will be looking to get points as quickly as they can, much like us.
"I have a lot of respect for Chris and it is a smashing football club. I haven't seen them that much but I will watch a few games now until we play them on Wednesday."
Pulis has guided Palace out of the bottom three since taking the helm, and he has been impressed with how the squad have adapted to his methods.
"The players' attitude to what we are trying to do as a group has been wonderful," he added.
"If you look at the running stats for the wide players it is getting to a point where it should be, and I ask the full-backs to get up and support.
"The team move up and down the pitch collectively and to do that you need people who are prepared to work and, with the position we are in, everyone has to work and they have bought into it and I think they are enjoying it."