Thistle secured promotion to the top flight, after nine years away, with a series of dominant displays last season, winning the Division One title by 11 points from Morton.
The match will see former boss Jackie McNamara return to the club he left in January of this year, with Alan Archibald taking over and leading them to the championship.
After their home opener, Archibald's team make the trip to Ross County seven days later and then host troubled Hearts, who could start the season with a 15-point deduction for going into administration.
The Jags' first clash with champions Celtic comes on October 26, at Firhill, with their first visit to Parkhead on New Year's Day after a pair of Christmas home games.
The busy spell starts with a Boxing Day encounter against Inverness and they are also at Firhill on December 29 when Europa League qualifiers Motherwell are the visitors.
Their final fixture before the league splits comes on April 5, when Hearts are again the visitors.